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Update time:2023-07-05
Current location : HomeProductsChromatography/Mass Spectrometry > Automated Hydrogen-Deuterium Exchange > Hydrogen-Deuterium Exchange Overview
HDX is a well-established analytical technique for protein-ligand, protein-protein, protein-conjugate interactions and protein stability studies.
HDX uses variations in deuterium exchange rates between more and less accessible/structured regions throughout a protein.
In addition to being faster than other protein techniques like X-Ray Crystalography and NMR, HDX data can be obtained from samples that are challenging to crystalize and from samples in short supply. It can be used to replicate critical native state conditions, for the most useful results. HDX is an indispensable complementary tool for protein biophysics.
HDX system is compatible with bottom-up, top- and middle-down protein analysis studies.
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